Houttuynia cordata Thunb. In China the herb is referred to as the ‘fishy smell herb’ owing to the foul fishy smell the leaves emit when pressed hard. This list contains plants that have been reported as having systemic effects on animals and/or intense effects on the gastrointestinal tract. Houttuynia cordata; distribution; herb-drug interaction; metformin; multidrug and toxin extrusion protein; organic cation transporter. Synthesis of 3-n-nonylpyrazole using nonyl-β-chlorovinyl ketone. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. and Shirai T, Thirteen-week oral toxicity study of Dokudami extract (Houttuynia cordata Thunb.) Broad agreement: comes from industry data where a majority of data submitters agree the substance is toxic to reproduction. Current investigation shows that the pharmacologically active ingredients of HC vapor extract might be α-terpineol and L-bornyl acetate, which reduced ALI and RPF, while IFN-γ and the TGF-β1/Smad pathway might be the pharmacological targets of HC. Recent studies indicate that H. cordata contains abundant nutrients and active components including volatile oils, flavonoids, and water soluble polysaccharides. (Fam. Within the class of flavonols, myricitin-3-galactoside is a topo1 poison [132]. 13. contains Houttuynia cordata, Qingfei Paidu decoc tion. Virucidal Effects of the Steam Distillate from Houttuynia cordata and its Components on HSV-1, Influenza Virus, and HIV. Houttuynia cordata is a rhizomatous perennial that typically grows 9-15” tall and spreads indefinitely and often vigorously by rhizomes. In LPS-induced rat RPF, HC vapor extract treatment evidently up-regulated the ratio of lymphocytes and mononuclear phagocytes at the 7th day, reduced the expression of TGF-β1 and Smad2/3, the content of lung Hyp (16.5 mg/kg) and serum LDH, and increased the expression of IFN-γ and Smad7 (Du et al., 2012). Due to the observed impact of flavones and flavonols on human type I and type II topoisomerase, it is most probable that the presence of a hydroxyl group at the 5- and/or 4′-position and the presence of additional hydroxyl moieties on the phenolic C6-ring at the 3′- and/or 5′-positions (Scheme 4.6) enhance the inhibitory activity on topo2β isoform [83]. Further treatment of sodium salt with hydrazine sulfate followed by addition of sodium hydroxide and acidification with hydrochloric acid afforded 3-n-nonyl pyrazole 195 in good yield (Scheme 32). Der Eidechsenschwanz (Houttuynia cordata) ist mit seinen gelb-roten Blättern eine äußerst dekorative Wasserpflanze. To elucidate whether there are more pharmacological effects of this plant, this study was therefore, carried out to determine the anti-hyperglycemic and anti-hyperlipidemic effects of 80% ethanol extract of H. cordata (HCE). In Scheme 4.6, the rules for “classical” and redox-dependent poisons are printed out. Flavones such as apigenin, luteolin, and baicalein are present in relatively small quantities in grains, leafy vegetables, and herbs [127]. The methanolic extract of M. charantia showed an inhibitory effect on DENV-1 by antiviral assay based on cytopathic effects. It can inhibit the growth of S. aureus, Moraxella catarrhalis, Haemophilus influenzae and Streptococcus pneumoniae (S. pneumoniae) in the clinic [101]. 2020 May 21;12(5):468. doi: 10.3390/pharmaceutics12050468. The impact of several flavones and flavonols on topoisomerase activity was demonstrated and different mechanisms of topoisomerase inhibition depending on the structure were reported. The plant is well known among the people of diverse cultures across Japan, Korea, China and North-East India for its medicinal properties. In in vivo rats, treatment with HCT and metformin for 28 days in rats (28MH rats) reduced the rat Oct2-mediated renal excretion of metformin and thereby the increased systemic exposure of metformin compared with only metformin-treated rats for 28 days (28M rats). 3) [102]. Moisturizer With SPF. Im Herbst verfärbt sich das Laub zumeist in ein kräftiges Rot, sodass es auch dann dekorative Akzente im Garten setzt. (2018) Chaiyasut et al. S. aureus promotes the production of autolysin through the overexpression of the lrga/cidA gene, which causes cell lysis, releases eDNA, and promotes other symbiotic bacterial subsets to form biofilms [104,105]. Recent real-world studies have demonstrated that add-on therapy with TCM proves an additive or synergistic effect compared with monotherapy in the prevention and therapy of cardiovascular diseases [84], cancers [85], and Alzheimer’s disease [86]. EWG's rating for Missha M Signature Real Complete BB Cream, Honey Beige, SPF 25 (2019 formulation) is 4. This review aims to provide up-to-date and comprehensive information on the efficacy of H. cordata extracts as well as its bioactive compounds both in vitro and in vivo, against oxidative stress and inflammation. (Saururaceae) (H. cordata), which is a widely used herbal medicine and is also popularly consumed as a healthy vegetable, exhibits anti-inflammatory, antioxidant and antitumor activity. Houttuynia cordata belongs to the Saururaceae family, possesses a number of medicinally important activities such as antiviral, anti-oxidant and inhibitory effects on anaphylactic reaction [25]. Der Eidechsenschwanz ist gut frostverträglich. Furthermore, SIE was found to have an anti-oxidant effect in a dose-dependent manner and not to be cytotoxic under 50 μg/ml. In line with previous studies, myricitin is characterized as a topo1 poison in a cell-free test system. 3. The EA fraction of H. cordata was tested for acute oral toxicity in C57BL/6 mice. However, an increase in the concentration of catalase was noted in the BALF. Hier finden Sie die Testsieger an Cordata, während der erste Platz unseren Favoriten ausmacht. On the other hand, SIE had non-antibiotic anti-microbial activity at a dose greater than 100 μg/ml on P. acnes [55]. Cancer . Both alkaloids bearing free phenolic groups, jatrorrhizine, and magnoflorine showed higher activities than berberine not bearing any readily abstractable hydrogen on its skeleton. Clin Pharmacokinet. Bensasson et al. 6. In the model of proinflammatory cytokine-induced monocytes, maximum suppression was obtained with A. indica and S. indicus, followed by H. indicus, R. cordifolia and C. longa, but A. vera had no inhibitory activity [49]. Various types of chemical constituents such as aristolactams, oxoaporphines, amides, indoles, ionones, flavonoids, benzenoids, steroids and different volatile oils have been isolated from its extract [ 26 ]. Foliage is aromatic when bruised. The observed inhibition of the relaxation step by the tested flavones is not due to intercalation with DNA, but rather to specific interactions with the enzyme or with the enzyme/DNA intermediate. The toxicity of Houttuynia cordata tea is very small, but Houttuynia cordata injection may cause allergic reactions, such as drug dermatitis, peripheral neuritis, allergic purpura and so on. Clipboard, Search History, and several other advanced features are temporarily unavailable. The actual smell and taste. Ist der Standort nicht entsprechend gewählt, muss deshalb großzügig gewässert werden, damit der Eidechsenschwanz gesund wachsen kann. These findings are supported by Lopez-Lazaro et al. TCM has been widely combined with Western medication, in part because of its remarkable curative effects and less side effects. It is primarily grown as a ground cover in moist to wet areas, including aquatic margins. y=1, n=-1: 1.03: Does the species have weedy races? The synergistic activity of Houttuynia cordata ethanol extract (HCT) and metformin combination in diabetic rats has been previously reported, but the fundamental causes remain unsolved. Im Herbst leuchten sie schön rot. Myricetin does not stabilize topo2α or topo2β cleavable complexes in cultured human cells, but acts as a poison in purified systems [83]. It was first described by Swedish researcher Carl Peter Thunberg in 1784. The synergistic activity of Houttuynia cordata ethanol extract (HCT) and metformin combination in diabetic rats has been previously reported, but the fundamental causes remain unsolved. Houttuynia cordata Thunb. Houttuynia cordata Thunb. Quercetin and apigenin slightly induce topo2–DNA complexes in K562 cells, with the highest efficiency after 2 h for quercetin and 0.5 h for apigenin. In a study of a water solution of HCP ethanol extract (wHCP), 1%, 5% and 10% wHCP significantly inhibited the formation of methicillin-resistant Staphylococcus aureus (MRSA) T31 and Fusarium nucleatum biofilms at 24 h in a concentration-dependent manner [100]. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms. No reported toxicity to: No reported toxicity to Birds HC volatile extract was applied to a LPS-induced rapid pulmonary fibrosis (RPF) rat model and analyzed its effect on ALI and RPF (Du et al., 2012) (Table 2). Action: To remove toxic heat, to promote the drainange of pus, and to relieve dysuria. In literature, a link between DNA intercalation and topo1 inhibition has been discussed. You might be right. Herbal medicines or plant products were traditionally being used for treating the oxidative stress and inflammation related diseases in diverse communities across the world. We use cookies to help provide and enhance our service and tailor content and ads. It has long been used in China both as an edible vegetable and in traditional medicine. Im Sommer kommen weiße schalenförmige Blüten dazu. The 5,6,7-trihydroxyflavone baicalein also exhibits a wide spectrum of cellular activities, including anti-inflammatory and anticarcinogenic properties [128–130]. R. cordifolia, C. longa, H. indicus and A. indica showed remarkable suppression of reactive oxygen species (ROS) from polymorphonuclear leukocytes. Houttuynia cordata. Answer: Score: 1.01: Is the species highly domesticated? Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Furthermore, the aromatic, planar C-ring with the ketone group at C4 position in the case of flavones/flavonols was proposed to form a pseudo ring with the C5 hydroxyl moiety that affords the interaction between the compound and topo2 [143,144]. We assess the ingredients listed on the labels of personal care products based on data in toxicity and regulatory databases, government and health agency assessments and the open scientific literature. For Lung abscess and tobacco toxicity combine houttuynia with fritillary bulbs (Chuan Bei Mu) and job's tears ... (1995). Family - Saururaceae. Developmental & Reproductive Toxicity . Furthermore, cells lacking topo2β are resistant toward the growth inhibitory properties of myricetin, indicating the beta isoform as a prominent cellular target [131]. Houttuynia grows natively in wet, warm parts of China as well as Nepal, India, Japan, Thailand and Indonesia. View article. NIH The methanolic extract of Vitis cinerea leaves, the ethanol extract of Tridax procumbens stems, and the ethanol extract of S phaeralcea angustifolia had activity against the virus [44]. Fig. Kaempferol does not have topo1 inhibitory properties up to 100 μg/mL [80]. Results derived from DNA-ligation assays show that luteolin, kaempferol, quercetin, or myricetin at a concentration of 50 μM affect topo2α and topo2β DNA ligation [83]. Scientifically, H. cordata has shown to target several signaling pathways and found to effectively reduce the oxidative stress and inflammation. nat.Toni Fischer, in, Traditional and Folk Medicine as a Target for Drug Discovery. Houttuynia cordata belongs to the Saururaceae family, possesses a number of medicinally important activities such as antiviral, anti-oxidant and inhibitory effects on anaphylactic reaction [25]. immune-stimulating (phagocytes), anti-inflammatory, diuretic, analgesic, haemostatic. The EA fraction of H. cordata was tested for acute oral toxicity in C57BL/6 mice. Furthermore, these compounds (luteolin, kaempferol, quercetin, myricetin) enhance DNA cleavage induced by both topo2α and topo2β, with a stronger activity of the respective flavonoids on the beta isoform. Bandele and Osheroff [83] show for the first time that luteolin, kaempferol, and quercetin at a concentration of 50 μM strongly increase the amount of topo2α and topo2β bound to DNA in human CEM leukemia cells using the in vivo complex of enzyme (ICE) bioassay. Thus, the combined ... Houttuynia cordata leaves were washed and dried in oven for 18 h at 50oC. eDNA is a DNA fragment derived from genomic DNA or exogenous gene transfer. Sie bildet kriechende, relativ dünne Rhizome als Überdauerungsorgane. The stems are green or shades of red and can be either smooth or pubescent. TCM as add-on therapy or monotherapy to Western medication (metformin) for the metabolic disorders associated with gut microbiota modulation. PDF | Silver nanoparticles (Ag-NPs) were synthesized in an eco-friendly manner using aqueous Houttuynia cordata leaf extract (HLE). Potentially toxic to reproduction: comes from a harmonised C&L classifying the substance as suspected toxic to reproduction Repr. Xanthohumol exhibited the highest activity in total oxygen radical absorbance capacity as well as singlet oxygen absorbance capacity [52]. 2. Relevant information on H. cordata against oxidative stress and inflammation were collected from the established scientific databases such as NCBI, Web of Science, ScienceDirect, Elsevier, and Springer. Objective: The present study was intended to evaluate the subchronic toxicity of Lactobacillus-mediated fermented Houttuynia cordata juice (FHJ) using rodent model system. Der gegliederte, longitudinal gerillte, manchmal purpurrötliche Stängel wächst im basalen Bereich kriechend und bildet an den Knoten (Nodi) Wurzeln; danach wächst er aufsteigend bis aufrecht und in diesem Bereich können die Knoten ka… 2019 Jan 15;127:282-290. doi: 10.1016/j.ejps.2018.11.010. In the study of the effects of houttuyniae herba, the aerial part of houttuynia cordata thunb. [131] show that myricetin acts as topo1 poison in K562 leukemia cells after 24 h of incubation using the TARDIS cell-based assay. Pharmaceutics. From these flavonoids, quercetin, kaempferol, and myricetin act as so-called topo2 poisons, stabilizing the covalent enzyme–DNA–intermediate determined in test systems using purified topoisomerase enzyme and DNA, as well as a cellular test using human leukemia cells. In addition, it is actually reminded that the individuals to prevent hot and spicy food in the process of taking standard Chinese herbal medicine, so as never to impact the efficacy from the treatments and so irritate the disease. Sphaeranthus indicus caused a weak significant suppression of ROS. Fishy smell and slightly astringent taste. Location. ZAC Wagner Wunderschöne Chamäleonpflanze Eidechsenschwanz (Houttuynia cordata) Sie erhalten von uns eine kräftige Einzelpflanze im 9 cm Topf. Therefore, pharmacological activity and systemic exposure of metformin in HCT … Please enable it to take advantage of the complete set of features! Epub 2019 Apr 17. had reported the synthesis of 195 by reacting nonyl-β-chlorovinyl ketone 196 with hydrazine hydrate 197 in the presence of potassium acetate using ethanol as a solvent followed by treatment with sodium hydroxide and extraction with ether resulted into the formation of desired product 195 [80] (Scheme 31). Houttuynia is a plant that also goes by its botanical name houttuynia cordata Thunb and Chinese name dokudami. Chemical structures of several flavones and flavonols. From: Biomedicine & Pharmacotherapy, 2018, Dr med.Carl-Hermann Hempen, Dr med., Dr sc.  |  2. Houttuynia cordata belongs to the Saururaceae family, possesses a number of medicinally important activities such as antiviral, anti-oxidant and inhibitory effects on anaphylactic reaction [25]. These results suggest that HCT-metformin combination therapy is applicable in terms of efficacy and safety. Houttuynia cordata, also known as fish mint, fish leaf, rainbow plant, chameleon plant, heart leaf, fish wort, or Chinese lizard tail, is one of two species in the genus Houttuynia (the other being H. emeiensis).It is a flowering plant native to Southeast Asia. A catalytic inhibition of eukaryotic type I topoisomerase activity (IC50 values: 110–260 μM) is reported for several flavonol glycosides derived from two Leguminosae extracts of Vicia faba and Lotus edulis. Houttuynia cordata is a rhizomatous perennial that typically grows 9-15” tall and spreads indefinitely and often vigorously by rhizomes. 13. These antiinflammatory and antibiofilm effects reduce the risk of oral infection developing into chronic systemic diseases. The young fruit rind extract contained significantly higher contents of phenolics and tannins and have higher free radical scavenging activity than the mature fruit rind extract but, the later extract contained higher contents of flavonoids and alpha-mangostin xanthone and exhibited higher anti-acne producing bacteria activity than the young fruit rind extract [51]. Pharmaceutics. More works should be done in the future to confirm the causal role of gut microbiota in add-on therapy with TCM. Houttuynia cordata mag es feucht bis nass. Liu-Cheng Li, Lian-Di Kan, in Journal of Ethnopharmacology, 2017. By continuing you agree to the use of cookies. FL: Flos Lonicera; SB, Scutellaria baicalensis; HC, Houttuynia cordata. While papaya leaf extract inhibits the bacterial infection that causes the fever, tawa-tawa extract prevents bleeding. The collected information is an attempt to cover recent developments in the pharmacology, phytochemistry and quality control of this species. OBJECTIVE: To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis. HCT inhibited human OCT2 and human MATE1-mediated metformin transports in vitro. Houttuynia cordata, E. odoratum and S. alata exhibited a moderate anti-oxidant activity. Xenobiotica. HM Lu, YZ Liang, LZ Yi, XJ Wu (2006). Species plants feature ovate to cordate dark blue-green leaves (to 3” long) edged with red. Phyto-constituents such as afzelin, hyperoside and quercitrin have shown to reduce inflammation both in vitro and in vivo models. As a traditional herb, H. cordata has a long history of application in China, Japan and other places. Myricetin acts as covalent topo1 poison stabilizing the enzyme/DNA cleavage complex, whereas for planar flavonoids such as quercetin or baicalein, DNA intercalative activities are proposed. Thunb is an important medicinal plant widely distributed in East Asia. Species plants feature ovate to cordate dark blue-green leaves (to 3” long) edged with red. Jin S, Lee S, Jeon JH, Kim H, Choi MK, Song IS. Er bevorzugt humosen, nährstoffreichen Boden in sonniger Lage. Houttuynia cordata is a very popular plant especially in this part of the world due to its supposedly incredible medicinal benefits that are attached to it. Considering a fact that the final development of SARS symptom is similar to that of PF, digging the role of HC or its vapor monomers in PF would be more attractive. Lonicera japonica extract increases metformin distribution in the liver without change of systemic exposed metformin in rats. Houttuynia cordata Thunb. Overall, the therapeutic efficacy of TCM as add-on therapy to MET for the metabolic disorders may be associated with the modulation of gut microbiota (Fig. Die Farbenpracht reicht von grün zu rot und gelb. However, differences in their respective mechanism of action have been reported. HM Lu, YZ Liang, LZ Yi, XJ Wu (2006). Predicted functional metagenomes showed the increased primary and secondary BA biosynthesis in SB + MET treatment group [88]. The active ingredients of the HC vapor extract included 4-terpineol, α-terpineol, L-bornyl acetate and methyl-n-nonyl ketone by gas chromatograph-mass spectrometer (GC-MS) (Du et al., 2012). Thus, exploring novel and effective candidate agents with low toxicity for chemoprevention is essential and urgent. The compounds in H. cordata contribute to the superior antiviral efficacy of the EA fraction which lacked cytotoxicity in vitro and acute toxicity in vivo. This ‘poison blocking herb’ is known for its miraculous properties since a long time ago. A kaempferol glycoside with an acetyl group linked to a sugar moiety is identified as the most potent catalytic inhibitor [138]. In vitro, HC vapor extract could inhibit the viability of RAW264.7 and NIH/3T3 cells, and dose-dependently decreased the expression of TGF-β1 and enhanced the expression of IFN-γ in NIH/3T3 embryonic FB (Du et al., 2012). Pharmaceutics. Scheme 32. 6). Asian Journal of Pharmaceutical and Clinical Research. NLM Passenderweise steht sie in der Familie der Saururaceae, zu Deutsch Eidechsenschwanzgewächse. Alteration in brain-derived neurotrophic factor (BDNF) after treatment of mice with herbal mixture containing Euphoria longana, Houttuynia cordata and Dioscorea japonica … In food, mainly the glycoside forms of the respective flavone/flavonol aglycons occur. CP: cyclophosphamide; FB: fibroblasts; GC-MS: gas chromatograph-mass spectrometer; GSH: glutathione; HC: Houttuynia cordata; IFN: interferon; iNOS: inducible nitric oxide synthase; PF: pulmonary fibrosis; LDH: lactate dehydrogenase; LPS: lipopolysaccharide; NS: Nigella sativa; SARS, severe acute respiratory syndrome; SP-D: surfactant protein-D; TGF-β1: transforming growth factor-β1; TNF-α: tumor necrosis factor-α, Lulu Zhang, ... Yong Tan, in Biomedicine & Pharmacotherapy, 2020. Alle der im Folgenden beschriebenen Cordata sind direkt bei Amazon im Lager und sofort bei Ihnen zuhause. In one study, the protective effects of this plant on BLM-induced pulmonary fibrosis in rats were evaluated. This finding suggests that H. cordata has no effect on the growth of these microorganisms. ZAC Wagner Wunderschöne Chamäleonpflanze Eidechsenschwanz (Houttuynia cordata) Sie erhalten von uns eine kräftige Einzelpflanze im 9 cm Topf. Lopez-Lazaro et al. Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class … From the perspective of gut microbiota, the synergistic mechanisms of a series of herbs, including Flos Lonicera (FL), S. baicalensis (SB), and Houttuynia cordata (HC), combined with MET on metabolic disorders were investigated [87–89]. Baicalein, luteolin, and quercetin are planar aromatic flavones/flavonols binding DNA by intercalation due to the presence of the double bond between the 2 and 3 carbon of the C-ring [134,135]. CCl 4-induced hepatotoxicity in animal models has been shown to be similar to human liver cirrhosis[6,7]. The main effect of SH on S. aureus was the inhibition of growth of S. aureus in suspended culture and the reduction in altruistic autolysis to release extracellular DNA (eDNA) during the formation of S. aureus biofilms in a dose-dependent manner (Fig.
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